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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3R1
All Species:
40.61
Human Site:
Y580
Identified Species:
99.26
UniProt:
P27986
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P27986
NP_852556.2
724
83598
Y580
L
R
K
T
R
D
Q
Y
L
M
W
L
T
Q
K
Chimpanzee
Pan troglodytes
XP_517729
724
83607
Y580
L
R
K
T
R
D
Q
Y
L
M
W
L
T
Q
K
Rhesus Macaque
Macaca mulatta
XP_001089423
724
83582
Y580
L
R
K
T
R
D
Q
Y
L
M
W
L
T
Q
K
Dog
Lupus familis
XP_850341
725
83693
Y581
L
R
K
T
R
D
Q
Y
L
M
W
L
T
Q
K
Cat
Felis silvestris
Mouse
Mus musculus
P26450
724
83396
Y580
L
R
K
T
R
D
Q
Y
L
M
W
L
T
Q
K
Rat
Rattus norvegicus
Q63787
724
83513
Y580
L
R
K
T
R
D
Q
Y
L
M
W
L
T
Q
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511081
737
83223
Y586
L
R
K
I
R
D
Q
Y
L
V
W
L
T
Q
K
Chicken
Gallus gallus
XP_424759
724
83782
Y580
L
R
K
T
R
D
Q
Y
L
M
W
L
T
Q
K
Frog
Xenopus laevis
Q8UUU2
722
83110
Y579
L
R
K
T
R
D
Q
Y
L
M
W
L
T
Q
K
Zebra Danio
Brachydanio rerio
XP_683819
727
83689
Y581
L
R
K
T
R
D
Q
Y
L
M
W
L
T
Q
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.1
95.5
N.A.
95.7
94.1
N.A.
62.1
89
80.6
78.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
100
99.5
97.9
N.A.
97.5
97.2
N.A.
77
95.7
91.8
89.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
86.6
100
100
100
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
100
100
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
100
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
100
0
0
0
0
0
0
0
0
0
0
0
100
% K
% Leu:
100
0
0
0
0
0
0
0
100
0
0
100
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
90
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
100
0
0
0
0
0
0
100
0
% Q
% Arg:
0
100
0
0
100
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
90
0
0
0
0
0
0
0
0
100
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
100
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _